NIMH Pages about Basic Research

Publications about Basic Research

Brain Development During Childhood and Adolescence (Fact Sheet)
A brain set in an outline of a woman’s profile. A fact sheet that describes the past, present and future of research on brain development.
Neuroimaging and Mental Illness: A Window Into the Brain
Neuroimaging FAQ Researchers use brain scans to study brain development in healthy people and people with illnesses. This publication answers frequently asked questions about what brain scans can and cannot do related to diagnosing mental illnesses.
A Participant's Guide to Mental Health Clinical Research
Participants Guide This brochure, prepared by the National Institute of Mental Health (NIMH), provides answers to common questions about volunteering for mental health clinical research.
Looking at My Genes: What Can They Tell Me?
A fact sheet containing frequently asked questions about genome scans and genetic testing.

Science News about Basic Research

Turning on Dormant Gene May Hold Key for Correcting a Neurodevelopmental Defect
Science Update • January 05, 2012
Angelman syndrome Scientists working in cell culture and in mice have been able to correct the loss of gene activity underlying a rare but severe developmental disorder by turning on a gene that is normally silenced in brain cells.
Biology, Not Just Society, May Increase Risk of Binge Eating During Puberty
Science Update • August 22, 2011
Lab rat sniffing cake frosting Biological changes associated with puberty may influence the development of binge eating and related eating disorders, according to a recent study on female rats conducted by NIMH-funded researchers.
New Neurons in Adult Brain Buffer Stress
Science Update • August 16, 2011
Photo of a mouse. New neurons growing in the adult brain help buffer the effects of stress, according to a new study in mice.
HIV-Infected Astrocytes Disrupt Blood-Brain Barrier, Contribute to Cognitive Impairment
Science Update • August 16, 2011
Microscope photo of astrocytes, a type of support cell in the brain. Astrocytes, a type of support cell in the brain, that are infected with HIV show abnormal connections and functioning that disrupt the blood-brain barrier, according to an NIMH-funded study.
Stress-Defeating Effects of Exercise Traced to Emotional Brain Circuit
Science Update • June 09, 2011
white and brown mice on a wheel Evidence in both humans and animals points to emotional benefits from exercise, both physical and mental. Now, in recent experiments with mice, scientists have traced the stress-buffering effect of activity to a brain circuit known to be involved in emotional regulation as well as mood disorders and medication effects. The finding is a clue to understanding the neurological roots of resilience, key to developing new means of prevention and treatment for stress-related illness.

Posts about Basic Research

The Long Paths to Breakthroughs

Balancing Immediate Needs with Future Innovation

NIMH’s Top 10 Research Advances of 2011

Treatment Development: The Past 50 Years

Dr. Insel discusses the state of psychiatric research and development (R&D) in the public and private sectors

Neuroscience Advances Showcased in Washington

Dr. Insel reflects on an exciting neuroscience conference where an increasing interest in neuropsychiatric disorders was evident.


Meeting Summaries about Basic Research

Alliance for Research Progress — July 29, 2011 Meeting
July 29, 2011
Bethesda, Maryland

Summary for the July 2011 meeting of the Alliance for Research Progress.
Navigating Your Way through a Successful Research Career: An NIMH Workshop for Early Stage Investigators
July 05, 2011 – July 06, 2011
Rockville, Maryland

On July 5-6, 2011, the Office for Research on Disparities and Global Mental Health (ORDGMH), in the Office of the Director of NIMH, sponsored a workshop for early stage investigators currently supported by Diversity and Re-entry Supplements, to provide the investigators with the tools necessary to continue along the path of competitive research support and the transition to independence. The workshop aimed to instill the importance of producing innovative research within the overall mission of the NIMH in these promising early career researchers. Content of the workshop emphasized issues relating to grantsmanship and strategies for successfully navigating obstacles and developing potential solutions on the journey to a successful research career.
Alliance for Research Progress — February 18, 2011 Meeting
February 18, 2011
Bethesda, Maryland

Summary for the February 2011 meeting of the Alliance for Research Progress.
The Maturation of Functional Brain Networks: Insight into the Origins and Course of Mental Disorders
January 27, 2011 – January 28, 2011
Washington, D.C.

Neural networks are a fundamental property of normal brain function, and dysregulated brain activity has been implicated in a wide array of mental disorders. In January 2011, NIMH convened a multi-disciplinary workshop of experts to discuss the opportunities and challenges of studying the maturation of neural networks in healthy and clinical populations. The workshop focused on non-invasive research tools, structure-function relationships, typical and atypical development, personalized biomarkers, and developmental connectivity maps.
Using Stem Cells to Model Psychiatric Disorders: NIH Grantees Meeting
October 26, 2010
Bethesda, Maryland

In October 2010, the NIMH convened a meeting of NIH grantees who use stem cells, particularly those derived from patients, as tools to identify fundamental molecular and cellular defects and the role of altered developmental processes in psychiatric disorders.

Director’s Updates about Basic Research

NIMH Grantees Elected to Membership in National Academy of Sciences

November 23, 2011

On May 3, 2011, nine NIMH grantees were among the 72 new members elected to the National Academy of Sciences, a private, non-profit organization of scientists and engineers dedicated to advancing science and promoting its uses for the greater good. The Academy also acts as an official advisor to the federal government on issues related to science and technology.

NIMH Grantees Elected to Membership in National Academy of Sciences

May 10, 2010

On April 27, 2010, three NIMH grantees were among the 72 new members elected to the National Academy of Sciences, a private, non-governmental organization of scientists and engineers dedicated to advancing science and promoting its uses for the greater good. The Academy also acts as an official advisor to the federal government on issues related to science and technology.

Linda Brady of NIMH Receives New Roadmap Compass Award

November 18, 2008

NIH Director Elias Zerhouni, MD, presented the first individual Roadmap Compass Award on October 24, 2008 to Linda Brady, Ph.D., director of the Division of Neuroscience and Basic Behavioral Science at NIMH, for her leadership and coordination of the Molecular Libraries Working Group.

National Advisory Mental Health Council Workgroup Issues Nine Recommendations to Strengthen Research Training

November 10, 2008

A workgroup of the National Advisory Mental Health Council (NAMHC) makes nine specific recommendations to strengthen the institute’s program in research training in a new report entitled “Investing in the Future” released on November 1, 2008.

Institute of Medicine of the National Academies Announces New Members

October 20, 2008

The Institute of Medicine (IOM) on October 13, 2008 announced the names of 65 new members and five foreign associates in conjunction with its 38th annual meeting.