NIMH Practical Clinical Trials

NIMH designed the practical clinical trials to examine changes in both symptoms and functioning to determine whether a treatment improves quality of life, care-giving burden, or use of health services.

These "effectiveness studies" are part of a rigorous effort to discover what therapies work best. The practical clinical trials are:

• CATIE
  Clinical Antipsychotic Trials of Intervention Effectiveness
• STAR*D
  Sequenced Treatment Alternatives to Relieve Depression Study
• STEP-BD
  Systematic Treatment Enhancement Program for Bipolar Disorder
• TADS
  Treatment for Adolescents with Depression Study
• TORDIA
  Treatment of SSRI-resistant Depression in Adolescents study